From the North (New England)
I-84 West to I-81 South to Exit 185

From the South (Allentown/Philadelphia)
Northeast Extension of the Pennsylvania Turnpike (I-476) to Exit 37
I-81 North to Exit 185

From the East (New York/New Jersey)
I-80 West to I-380 West to I-81 South to Exit 185

From the West (Danville/State College)
I-80 East to I-81 North to Exit 185

From I-81 Exit 185
Stay in right lane.  Follow signs for Jefferson Avenue and the University of Scranton campus.  You will see the campus on your right.  Turn right on Jefferson Avenue at the 1st traffic light.  Proceed to 2nd traffic light and turn right onto Mulberry Street (Houlihan McLean Center is on the corner).  Immediately past the Houlihan McLean Center, make 1st right into Moir Court.  The Cancer Institute's parking lot will be located on the right.

The Northeast Regional Cancer Institute office is located on the University of Scranton Campus at 334 Jefferson Avenue.

Wilkes-Barre Office
63 North Franklin Street, Kirby Health Center, Wilkes-Barre, PA 18701

From SCRANTON: Take 81S to Route 309N (Wilkes-Barre Exit #170B). This puts you on the Cross Valley Expressway. Exit off the expressway at the Wilkes-Barre Center City Exit (Exit 2). At the light at the end of the exit, make a left. You are now on Wilkes-Barre Boulevard. Please follow the directions below from Wilkes-Barre Boulevard.

From HAZLETON: Take 81N to Route 309N (Wilkes-Barre Exit #170B). This puts you on the Cross Valley Expressway. Exit off the expressway at the Wilkes-Barre Center City Exit (Exit 2). At the light at the end of the exit, make a left. You are now on Wilkes-Barre Boulevard. Please follow the directions below from Wilkes-Barre Boulevard.

From TUNKHANNOCK: Take 29S to Route 309S. Continue on 309S to the Cross Valley Expressway. Exit off the expressway at the Wilkes-Barre Center City Exit (Exit 2). At the end of the exit, bear right and you will be on Wilkes-Barre Boulevard. Please follow the directions below from Wilkes-Barre Boulevard.

From BLAKESLEE: Take State Highway 115N to Route 309N. This puts you on the Cross Valley Expressway. Exit off the expressway at the Wilkes-Barre Center City Exit (Exit 2). At the light at the end of the exit, make a left. You are now on Wilkes-Barre Boulevard. Please follow the directions below from Wilkes-Barre Boulevard.

From WILKES-BARRE BOULEVARD:
Proceed until you reach Market Street. At Market Street, make a right. At the third light, you will be at Public Square. Make a right. Go two sides of the square and make a right back onto Market Street. At the first light, make a right. This is North Franklin Street. Kirby Health Center is about the sixth building on the right hand side. (Granite building with a blue tile roof.) Turn right onto the cobblestone driveway next to the building. Parking is provided in the rear of the building.